Affiliation:
1. Universidade Federal de Sao Joao del-Rei, Campus Centro-Oeste Dona Lindu, Divinopolis, Minas Gerais, Brazil
2. Department of Psychobiology (Departamento de Psicobiologia), Universidade Federal de Sao Paulo, Sao Paulo, Sao Paulo, Brazil
Abstract
There are several studies investigating the effects of risperidone on autism, but many of
these studies are contradictory or inconclusive. This systematic review and meta-analysis investigated
the effects of risperidone on five domains of the Aberrant Behaviour Checklist (ABC) scale
on Autism Spectrum Disorder (ASD), as well as weight gain and waist circumference. The protocol
for the present systematic review and meta-analysis was registered on the International Prospective
Register of Systematic Reviews (PROSPERO). For this study, we analysed articles (2,459), selecting
them according to the PICOS strategy (Population, Intervention, Comparison, Outcome, Study
design). Although risperidone is effective for the treatment of lethargy and inadequate speech, concerns
about the association between weight gain, waist circumference and risperidone require a
need for evaluation of the risk-benefit ratio in its use. There was a significant association between
weight gain, waist circumference and risperidone. In conclusion, it was possible to suggest the efficacy
of risperidone for the treatment of lethargy and inadequate speech. Finally, we emphasize that
the risk-benefit in its use should be evaluated (Protocol number CRD42019122316).
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmacology (medical),Psychiatry and Mental health,Neurology (clinical),Neurology,Pharmacology,General Medicine
Cited by
19 articles.
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