Effects of Risperidone in Autistic Children and Young Adults: A Systematic Review and Meta-Analysis

Author:

Mano-Sousa Brayan Jonas1,Pedrosa Alessandra Moraes1,Alves Bruna Cristina1,Galduróz José Carlos Fernandes2,Belo Vinícius Silva1,Chaves Valéria Ernestânia1,Duarte-Almeida Joaquim Maurício1

Affiliation:

1. Universidade Federal de Sao Joao del-Rei, Campus Centro-Oeste Dona Lindu, Divinopolis, Minas Gerais, Brazil

2. Department of Psychobiology (Departamento de Psicobiologia), Universidade Federal de Sao Paulo, Sao Paulo, Sao Paulo, Brazil

Abstract

There are several studies investigating the effects of risperidone on autism, but many of these studies are contradictory or inconclusive. This systematic review and meta-analysis investigated the effects of risperidone on five domains of the Aberrant Behaviour Checklist (ABC) scale on Autism Spectrum Disorder (ASD), as well as weight gain and waist circumference. The protocol for the present systematic review and meta-analysis was registered on the International Prospective Register of Systematic Reviews (PROSPERO). For this study, we analysed articles (2,459), selecting them according to the PICOS strategy (Population, Intervention, Comparison, Outcome, Study design). Although risperidone is effective for the treatment of lethargy and inadequate speech, concerns about the association between weight gain, waist circumference and risperidone require a need for evaluation of the risk-benefit ratio in its use. There was a significant association between weight gain, waist circumference and risperidone. In conclusion, it was possible to suggest the efficacy of risperidone for the treatment of lethargy and inadequate speech. Finally, we emphasize that the risk-benefit in its use should be evaluated (Protocol number CRD42019122316).

Publisher

Bentham Science Publishers Ltd.

Subject

Pharmacology (medical),Psychiatry and Mental health,Neurology (clinical),Neurology,Pharmacology,General Medicine

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