Affiliation:
1. Department of Biochemistry, Center of Biological Sciences, Federal University of Santa Catarina, 88040-900, Florianópolis-SC, Brazil
Abstract
Heme oxygenase (HO) family catalyzes the conversion of heme into free iron, carbon monoxide and
biliverdin. It possesses two well-characterized isoforms: HO-1 and HO-2. Under brain physiological conditions,
the expression of HO-2 is constitutive, abundant and ubiquitous, whereas HO-1 mRNA and protein are restricted
to small populations of neurons and neuroglia. HO-1 is an inducible enzyme that has been shown to participate as
an essential defensive mechanism for neurons exposed to oxidant challenges, being related to antioxidant defenses
in certain neuropathological conditions. Considering that neurodegenerative diseases (Alzheimer’s Disease
(AD), Parkinson’s Disease (PD) and Multiple Sclerosis (MS)) and neuropsychiatric disorders (depression, anxiety,
Bipolar Disorder (BD) and schizophrenia) are associated with increased inflammatory markers, impaired
redox homeostasis and oxidative stress, conditions that may be associated with alterations in HO-levels/activity,
the purpose of this review is to present evidence on the possible role of HO-1 in these Central Nervous System
(CNS) diseases. In addition, the possible therapeutic potential of targeting brain HO-1 is explored in this review.
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,Pharmacology
Cited by
26 articles.
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