Affiliation:
1. Department of Stem Cells and Regenerative Medicine, College of Basic Medical Science, China Medical University, Shenyang, China
2. Department of Anesthesiology, the First Affiliated Hospital of China Medical University, Shenyang, China
Abstract
MicroRNA (miRNA/miR) is a class of small evolutionarily conserved non-coding RNA, which can
inhibit the target gene expression at the post-transcriptional level and serve as significant roles in cell differentiation,
proliferation, migration and apoptosis. Of note, the aberrant miR-21 has been involved in the generation and
development of multiple lung diseases, and identified as a candidate of biomarker, therapeutic target, or indicator
of prognosis. MiR-21 relieves acute lung injury via depressing the PTEN/Foxo1-TLR4/NF-κB signaling cascade,
whereas promotes lung cancer cell growth, metastasis, and chemo/radio-resistance by decreasing the expression
of PTEN and PDCD4 and promoting the PI3K/AKT transduction. The purpose of this review is to elucidate the
potential mechanisms of miR-21 associated lung diseases, with an emphasis on its dual regulating effects, which
will trigger novel paradigms in molecular therapy.
Funder
Basic Research Project of Liaoning Higher School
Provincial Key Research and Development Program Guidance Project
National Natural Science Foundation of China
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,Pharmacology
Cited by
7 articles.
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