Affiliation:
1. Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management,
SVKM’s NMIMS, V.L. Mehta Road, Vile Parle (W), Mumbai, India
Abstract
Background:
Genetically modified micro-organisms like bacteria, viruses, algae and fungi are novel
approaches used in the field of healthcare due to better efficacy and targeted delivery in comparison to conventional
approaches.
Objectives:
This review article focuses on the applications of genetically modified micro-organisms in the
treatment of cancer, obesity and HIV infection. The gut microbiome causes metabolic disorders, however, the
use of genetically modified bacteria alters the gut microbiota and delivers therapeutically effective drugs in the
treatment of obesity.
Methods:
Enhancement of the therapeutic activity of different micro-organisms is required for multiple treatments
in cancer, diabetes, etc., by incorporating their fragments into the microbial filaments with the help of
genetic modification approaches. Various methods like amelioration of NAPE synthesis, silica immobilization,
polyadenylation and electrochemical are used to integrate the strain into the bacteria and engineer a live virus
with a peptide.
Results:
The development of novel microbial strains using genetic modifications over core strains offers higher
precision, greater molecular multiplicity, better prevention from the degradation of microbes in atmospheric
temperature and significant reduction of side effects for therapeutic applications. Moreover, genetically modified
micro-organisms are used in multidisciplinary sectors like generation of electricity, purification of water,
bioremediation process, etc., indicating the versatility and scope of genetically engineered microbes.
Conclusion:
The bioengineered micro-organisms with genetic modifications proved to be advantageous in various
conditions like cancer, diabetes, malaria, organ regeneration, inflammatory bowel disease, etc. This article
provides insight into various applications of genetically modified microbes in different sectors with their implementation
for regulatory approval.
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,Pharmacology
Cited by
1 articles.
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