Study on the Interaction between Silibinin and Neuraminidase-Reference-Cited by-同舟云学术

Study on the Interaction between Silibinin and Neuraminidase

Published:2023-02 Issue:16 Volume:29 Page:1266-1273
ISSN:1381-6128
Container-title:Current Pharmaceutical Design
language:en
Short-container-title:CPD

Author:

Fang Haowen¹²,Ding Yanting¹³⁴,Lu Yi²,Niu Bing²,Lu Han⁵,Chen Qin²

Affiliation:

1. School of Environmental and Chemical Engineering, Shanghai University, Shanghai, P.R. China

2. School of Life Sciences, Shanghai University, Shanghai, P.R. China

3. Tongji Hospital, School of Medicine, Tongji University, Shanghai, P.R. China

4. Shanghai Biochip Co., Ltd., National Engineering Center for Biochip at Shanghai, Shanghai, P.R. China

5. Department of Anesthesiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China

Abstract

Background: Neuraminidase is a pathogenic protein of the avian influenza virus. Previous studies have shown that silibinin has the potential to inhibit neuraminidase activity. Objective: This study aims to explore the interaction between silibinin and neuraminidase and the effect of silibinin on the structure and activity of neuraminidase. Methods: In this study, two-dimensional fluorescence spectrum, three-dimensional fluorescence spectrometry, Uv-vis spectroscopy, and Circular dichroism analysis were used. Results: Silibinin alters the secondary structure of neuraminidase and inhibits the activity of neuraminidase. Conclusion: Silibinin can interact with neuraminidase and inhibit its activity.

Funder

National Natural Science Foundation of China

Publisher

Bentham Science Publishers Ltd.

Subject

Drug Discovery,Pharmacology

Reference38 articles.

1. Xie Y.; Gong J.; Li M.; Fang H.; Xu W.; The medicinal potential of influenza virus surface proteins: hemagglutinin and neuraminidase. Curr Med Chem 2011,18(7),1050-1066

2. Wang K.; Lei Z.; Zhao L.; Design, synthesis and biological evaluation of oseltamivir derivatives containing pyridyl group as potent inhibitors of neuraminidase for influenza A. Eur J Med Chem 2020,185,111841

3. de Freitas C.S.; Rocha M.E.N.; Sacramento C.Q.; Marttorelli A.; Ferreira A.C.; Rocha N.; Agathisflavone, a biflavonoid from Anacardium occidentale L., inhibits influenza virus’ neuraminidase. Curr Top Med Chem 2019,20(2),111-120

4. Sacramento C.Q.; Jordao A.K.; Abrantes J.L.; Alves C.M.; Marttorelli A.; Fintelman-Rodrigues N.; Neuraminidase from Influenza A and B viruses is susceptible to the compound 4-(4-Phenyl-1H-1,2,3-Triazol-1-yl)-2,2,6,6-Tetramethylpiperidine-1-Oxyl. Curr Top Med Chem 2019,20(2),132-139

5. Tran-Nguyen V.K.; Le M.T.; Tran T.D.; Truong V.D.; Thai K.M.; Peramivir binding affinity with influenza A neuraminidase and research on its mutations using an induced-fit docking approach. SAR QSAR Environ Res 2019,30(12),899-917