Affiliation:
1. Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, Collaborative Innovation Center of Chemical Science and Engineering, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072,China
2. School of Environmental Science and Engineering, Tianjin University, Tianjin 300072,China
Abstract
:
The ryanodine receptor (RyR) is one of the primary targets of commercial insecticides. The diamide
insecticide family, including flubendiamide, chlorantraniliprole, cyantraniliprole, etc., targets insect RyRs and
can be used to control a wide range of destructive agricultural pests. The diamide insecticides are highly selective
against lepidopteran and coleopteran pests with relatively low toxicity for non-target species, such as mammals,
fishes, and beneficial insects. However, recently mutations identified on insect RyRs have emerged and
caused resistance in several major agricultural pests throughout different continents. This review paper summarizes
the recent findings on the structure and function of insect RyRs as insecticide targets. Specifically, we
examine the structures of RyRs from target and non-target species, which reveals the molecular basis for insecticide
action and selectivity. We also examine the structural and functional changes of RyR caused by the resistance
mutations. Finally, we examine the progress in RyR structure-based insecticide design and discuss how
this might help the development of a new generation of green insecticides.
Funder
National Natural Science Foundation of China
Natural Science Foundation of Tianjin China
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,Pharmacology
Cited by
16 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献