Affiliation:
1. Graduate Program in Pharmaceutical Sciences, State University of Paraiba, Campina Grande, PB, Brazil
2. Department of Pharmacy, Laboratory of Development and Characterization of Pharmaceutical Products, State University of Paraiba, Campina Grande, PB, Brazil
3. Graduate Program in Health Science, Federal University of Rio Grande do Norte, Natal, RN, Brazil
Abstract
Surfactants are amphiphilic molecules of great interest in the pharmaceutical field which are used in
combination with other adjuvants to solubilize poorly soluble drugs, improve their dissolution profile, promote
permeation, improve drug delivery, enhance stabilization, among other characteristics. Literature shows that surfactants
are included in several pharmaceutical compositions: tablets, solid dispersions, emulsions, microemulsions,
nanoemulsions, liposomes and niosomes. This review aims to elucidate the different classes of surfactants
based on their charges (cationic, anionic, nonionic, zwitterionic, and dimeric), the micelles formation process,
and how surfactant molecules geometry can affect this phenomenon. Moreover, current studies regarding
the benefits of surfactants in the development of formulations are presented. Finally, a discussion on how
charges and chain length of surfactants can affect the stratum corneum epithelial cells leading to increased
permeation or skin irritability is reported.
Funder
Higher Education Personnel - Brazil
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,Pharmacology
Cited by
3 articles.
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