Role of Dietary Antioxidants in Neurodegenerative Diseases: Where are We Standing?

Author:

Bakir Sena1,Catalkaya Gizem1,Ceylan Fatma D.1,Khan Haroon2,Guldiken Burcu1,Capanoglu Esra1ORCID,Kamal Mohammad A.3ORCID

Affiliation:

1. Department of Food Engineering, Faculty of Chemical and Metallurgical Engineering, Istanbul Technical University, 34469 Maslak, Istanbul, Turkey

2. Department of Pharmacy, Abdul Wali Khan University Mardan 23200, Pakistan

3. King Fahd Medical Research Center, King Abdulaziz University, P.O. Box 80216, Jeddah 21589, Saudi Arabia

Abstract

: This review presents the potential effects of dietary antioxidants on neurodegenerative diseases. The relationship between autoimmunity and antioxidants, and their preventive effect on neurodegenerative diseases are evaluated. The driven factors of neurodegeneration and the potential effects of natural antioxidants are summarized for Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, spongiform encephalopathy, Huntington’s disease, and amyotrophic lateral sclerosis. The effect of oxidative stress on neurodegenerative diseases and regulative effect of antioxidants on oxidative balance is discussed. This review provides beneficial information for the possible cure of neurodegenerative diseases with dietary intake of antioxidants.

Publisher

Bentham Science Publishers Ltd.

Subject

Drug Discovery,Pharmacology

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