Pathways Involved in Premature Ovarian Failure: A Systematic Review of Experimental Studies

Author:

Pargianas Michail1ORCID,Salta Styliani2ORCID,Apostolopoulou Katerina3ORCID,Lazaros Leandros4ORCID,Kyrgiou Maria5ORCID,Tinelli Andrea6ORCID,Malvasi Antonio6ORCID,Kalogiannidis Ioannis7ORCID,Georgiou Ioannis4ORCID,Kosmas Ioannis P.6ORCID

Affiliation:

1. Department of Obstetrics and Gynecology, Ioannina State General Hospital G. Chatzikosta, Ioannina, Greece

2. University Hospitals of Leicester, Haemophilia Centre, Leicester Royal Infirmary, Leicester, United Kingdom

3. Department of Biological Applications and Technologies, Ioannina University, Ioannina, Greece

4. Genetics and IVF Unit, Department of Obstetrics and Gynecology, Medical School, Ioannina University, Ioannina, Greece

5. West London Gynecological Cancer Center, Queen Charlotte's and Chelsea-Hammersmith Hospital, Imperial Healthcare NHS Trust, London, United Kingdom

6. Moscow Institute of Physics and Technology (State University), Moscow Region, Russian Federation

7. Third Department of Obstetrics and Gynaecology, Faculty of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece

Abstract

Premature ovarian failure (POF), which may be undetectable for a long time, is associated with impaired fertility. The mechanisms involved in the pathogenesis of POF as well as the concomitant treatments are still unclear. Although many data exist, mainly produced by the study of transgenic animals under various experimental conditions, they remain fragmented. A systematic review of the pathways involved in premature ovarian failure was conducted. Data extraction was performed from experimental studies until 2019. The molecular processes and their correlation with the follicular developmental stage have been described. Furthermore, the effects in other cells, such as oocytes, granulosa and theca cells have been reported. An overall estimation was conducted.

Publisher

Bentham Science Publishers Ltd.

Subject

Drug Discovery,Pharmacology

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