Affiliation:
1. Health Sciences Post-Graduate Program, Federal University of Sergipe, Claudio Batista St s/n, CEP 49060-100, Aracaju, SE, Brazil
Abstract
Carvacrol has a high therapeutic potential, with in vitro studies showing promising results in different
cellular models using a variety of methodological designs. Therefore, the objective of this study was to conduct a
systematic review to analyze the pharmacological effects of carvacrol in in vitro studies. A comprehensive search
of the literature was made using four databases: Science Direct, Scopus, MEDLINE-PubMed, and Web of Science
using different combinations of the following keywords: carvacrol, drug therapy, therapeutic uses, in vitro
study. The search of the databases was for studies conducted in the period up to and including September 2016. A
total of 3,269 studies were initially identified, with only 31 meeting the inclusion criteria. The included studies
contained a variety of in vitro models able to determine the properties of Carvacrol. The following properties of
Carvacrol were identified: antimicrobial (7 studies), bactericidal (4), bactericidal and antifungal (1), antiinflammatory
(4), anticancer (4), mutagenic (4), antioxidant (3), antifungal (3), antidepressant (1), as a modulator
of nerve impulses (1) and an immunological modulator (1). The In vitro studies with Carvacrol included in this
review showed a diversity of models and confirmed the therapeutic potential of this product in relation to several
diseases.
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,Pharmacology
Cited by
30 articles.
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