Affiliation:
1. Optical Molecular Imaging, Department of Radiology and Nuclear Medicine, Erasmus Medical Center, Rotterdam, Netherlands
Abstract
:
Macrophages play a role in almost every disease such as cancer, infections, injuries, metabolic and inflammatory diseases and are becoming an attractive therapeutic target. However, understanding macrophage diversity, tissue distribution and plasticity will help in defining precise targeting strategies and effective therapies. Active targeting of macrophages using nanoparticles for therapeutic purposes is still at its infancy but holds promises since macrophages have shown high specific uptake of nanoparticles. Here we highlight recent progress in active nanotechnology-based systems gaining pivotal roles to target diverse macrophage subsets in diseased tissues.
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,Pharmacology
Reference106 articles.
1. Wynn T.A.; Chawla A.; Pollard J.W.; Macrophage biology in development, homeostasis and disease. Nature 2013,496(7446),445-455
2. Hume DA; Irvine KM; Pridans C; The mononuclear phagocyte system: The relationship between monocytes and macrophages. Trends Immunol 2018; pii: S1471-4906(18): 30226-6
3. Gordon S.; The macrophageast, present and future. Eur J Immunol 2007,37(Suppl. 1),S9-S17
4. Gentek R.; Molawi K.; Sieweke M.H.; Tissue macrophage identity and self-renewal. Immunol Rev 2014,262(1),56-73
5. Epelman S.; Lavine K.J.; Randolph G.J.; Origin and functions of tissue macrophages. Immunity 2014,41(1),21-35
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