Affiliation:
1. Department of Pharmaceutical Chemistry, C.L. Baid Metha College of Pharmacy, Chennai- 600097
Abstract
Background:
Globally, cancer is the leading cause of death, which causes 10 million
deaths yearly. Clinically, several drugs are used in treatment but due to drug resistance and
multidrug resistance, there occurs a failure in the cancer treatment.
Objectives:
The present review article is a comprehensive review of pyrazole and pyrimidine
hybrids as potential anticancer agents.
Method:
The review comprises more than 60 research works done in this field. The efficiency of
the reported pyrazolopyrimidine fused heterocyclic with their biological data and the influence of
the structural aspects of the molecule have been discussed.
Result:
This review highlighted pyrazolo-pyrimidines as targeted anticancer agents with effect on
multiple targets.
Conclusion:
The review will be helpful for the researchers involved in targeted drugs for cancer
therapy for designing new scaffolds with pyrazolo-pyrimidine moieties.
Publisher
Bentham Science Publishers Ltd.