Affiliation:
1. Graduate Program in Pharmaceutical Sciences, School of Pharmacy, Federal University of Rio Grande do Sul, Av. Ipiranga, Santana, 2752, Porto Alegre, Rio Grande do Sul, Brazil
Abstract
:
The human nail is a unique barrier with a keratinized constitution that favors protection and
fine touch. However, many disorders can affect the nail, among them, are the onychomycosis and psoriasis.
Systemic oral therapy has been applied to treat these diseases, even presenting disadvantages,
including side effects, drug interactions, contraindications, toxicity, high cost and low patient compliance.
A great option to succeed in dealing with the problems associated with oral therapy is the topical
administration of drugs. However, nail composition, low diffusion through ungual route and reduced
tissue bioavailability for topical treatments are limiting factors. These drawbacks can be overcome by
promoting penetration through the nails by employing penetration enhancers. The review focuses on
patents that highlight permeation enhancers applied to nail drug delivery for the treatment of onychomycosis
and psoriasis. Literature and patent searches were conduced regarding the topic of interest.
The substantial literature and patent search revealed that permeation enhancers, especially chemicals,
are great strategies for promoting the ungual delivery of drugs. Nail topical therapy containing permeation
enhancers is an attractive option for delivering localized treatments.
Funder
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmaceutical Science,Biomedical Engineering,General Medicine
Reference100 articles.
1. Murthy S.N.; Maibach H.I.; Topical nail products and ungual drug delivery 2013
2. Shanbhag P.P.; Jani U.; Drug delivery through nails: Present and future. New Horiz Transl Med 2017,3,252-263
3. Murdan S.; Drug delivery to the nail following topical application. Int J Pharm 2002,236(1-2),1-26
4. Lipner S.R.; Scher R.K.; Onychomycosis: Clinical overview and diagnosis. J Am Acad Dermatol 2019,80(4),835-851
5. Jiaravuthisan M.M.; Sasseville D.; Vender R.B.; Murphy F.; Muhn C.Y.; Psoriasis of the nail: Anatomy, pathology, clinical presentation, and a review of the literature on therapy. J Am Acad Dermatol 2007,57(1),1-27
Cited by
11 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献