Roles of Mesenchymal Stem Cells in Breast Cancer Therapy: Engineered Stem Cells and Exosomal Cell-Free Based Therapy-Reference-Cited by-同舟云学术

Roles of Mesenchymal Stem Cells in Breast Cancer Therapy: Engineered Stem Cells and Exosomal Cell-Free Based Therapy

Published:2024-01-24 Issue: Volume:24 Page:
ISSN:1566-5240
Container-title:Current Molecular Medicine
language:en
Short-container-title:CMM

Author:

Fath Mohsen Karami¹,Zadian Seyed Sajjad²,Torbati Samaneh Mohammad Bagherzadeh³,Saqagandomabadi Vahid⁴,Afshar Omid Yousefi⁵,Khalilzad Mohammad⁶,Abedi Sara⁷,Moliani Afshin⁸,Barati Ghasem⁹

Affiliation:

1. Department of Cellular and Molecular Biology, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran

2. Department of Immunology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

3. Faculty of Medicine, Babol University of Medical Sciences, Mazandaran, Iran

4. Department of Biomedicine, Neuroscience and Advanced Diagnostics, University of Palermo, Palermo, Italy

5. Clinical Research Development Unit, Valiasr Hospital, Tabriz, Iran

6. Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

7. Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran

8. Isfahan Medical Students Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

9. Stem Cell Technology Research Center, Tehran, Iran

Abstract

Abstract: Breast cancer has a high prevalence among women, with a high mortality rate. The number of people who suffer from breast cancer disease is increasing, whereas metastatic cancers are mostly incurable, and existing therapies have unfavorable side effects. For an extended duration, scientists have dedicated their efforts to exploring the potential of mesenchymal stem cells (MSCs) for the treatment of metastatic cancers, including breast cancer. MSCs could be genetically engineered to boost their anticancer potency. Furthermore, MSCs can transport oncolytic viruses, suicide genes, and anticancer medicines to tumors. Extracellular vesicles (EVs) are MSC products that have attracted scientist's attention as a cell-free treatment. This study narratively reviews the current state of knowledge on engineered MSCs and their EVs as promising treatments for breast cancer.

Publisher

Bentham Science Publishers Ltd.