Ribosomal DNA and Neurological Disorders-Reference-Cited by-同舟云学术

Ribosomal DNA and Neurological Disorders

Published:2024-05-21 Issue: Volume:24 Page:
ISSN:1566-5240
Container-title:Current Molecular Medicine
language:en
Short-container-title:CMM

Author:

Zhou Hong¹²³⁴,Xia Yuqing¹²³⁴^ORCID,Zhu Rui¹²³⁴^ORCID,Zhang Yuemei¹²³⁴,Zhang Xinming¹²³⁴,Zhang Yongjian¹²³⁴,Wang Jun¹²³⁴

Affiliation:

1. Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), Hubei University of Technology, Wuhan 430030, Hubei, China

2. International Center for Redox Biology &Precision Medicine of Hubei Province, Hubei University of Technology, Wuhan 430030, Hubei, China

3. National “111” Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei University of Technology, Wuhan 430030, Hubei, China

4. Department of Biomedicine and Biopharmacology, Hubei University of Technology, Wuhan 430030, Hubei, China

Abstract

Abstract: Ribosomal DNA (rDNA) is important in the nucleolus and nuclear organization of human cells. Defective rDNA repeat maintenance has been reported to be closely associated with neurological disorders, such as Alzheimer’s disease, Huntington’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, frontotemporal dementia, depression, suicide, etc. However, there has not been a comprehensive review on the role of rDNA in these disorders. In this review, we have summarized the role of rDNA in major neurological disorders to sort out the correlation between rDNA and neurological diseases and provided insights for therapy with rDNA as a target.

Publisher

Bentham Science Publishers Ltd.