Parkinson Disease: Molecular Biology, Pathophysiology and Biomarkers

Abstract

Parkinson disease is a progressive neurodegenerative disorder that affects motor control of the body. The disorder is associated with the loss of neurons due to formation of protein aggregates that leads to the development of apoptosis and degeneration of the neurons. The disease progresses slowly, making it difficult to identify it at early stage. But the availability of potential therapeutic biomarkers in analysis and early identification of PD is of great importance. The current review discusses here the molecular biology, pathophysiology and availability of potential biomarkers associated with the PD condition.