Zingiberene, an Active Constituent from Zingiber officinale Ameliorated High-Fat Diet-Induced Obesity Cardiomyopathy in Rats

Abstract

In the current study, we evaluated the effect of Zingiberene (ZB) is, a monocyclic sesquiterpene that is the principal constituent of ginger (Zingiber officinale), against high-fat-diet (HFD)-induced obesity cardiomyopathy (OC) in rats. ZB (50mg/kg/BW) was supplemented on obese rats for the period of 45 days and assessed its effect of body weight, anthropometrical and morphological parameters along with hyperglycemic markers. We also evaluated the effect of ZB on cardiac lipotoxicity and oxidative stress in cardiac tissue. The current study demonstrated that HFD supplementation significantly increased body weight, anthropometrical and morphological parameters, together developed hyperglycemia in rats. On the other hand, ZB supplementation in obese rats attenuated these altered parameters and ameliorated cardiac lipotoxicity as well as oxidative stress by decreasing lipid profiles of heart and enhancing the activities of endogenous antioxidant enzymes in the heart. Therefore, this study suggest that ZB might ameliorate the diet induced OC through the restoration of antioxidant system of the heart and attenuation of dyslipidemia in the cardiac.