Affiliation:
1. The First Laboratory of Cancer Institute, The First Hospital of China Medical University, Shenyang, 110001, China
2. Department of Anorectal Surgery, the First Hospital of China Medical University, Shenyang, 110001, China
Abstract
Background:
PTK7 (Protein Tyrosine Kinase 7), a member of the receptor
protein tyrosine kinase family, was originally discovered in colon cancer cells. It plays a
pivotal role in numerous developmental and physiological processes, particularly in the
regulation of cell polarity. Despite accumulating evidence of PTK7's significant influence
on tumor development, a comprehensive pan-cancer analysis of PTK7 has yet to be
conducted.
Methods:
We conducted a comprehensive analysis of PTK7's expression, prognostic value,
and mutational patterns across various tumor types. We further explored the correlations
between PTK7 expression and tumor stemness, immune-related genes, immune
scores, and immune cell infiltration.
Results:
Enrichment analysis revealed PTK7's critical involvement in pan-cancer functions
and processes, including the WNT pathway, Epithelial-Mesenchymal Transition
(EMT), and cell polarity regulation. Additionally, we validated PTK7's expression in
gastric cancer via immunohistochemistry.
Conclusion:
Our study indicates that PTK7 holds promise as an ideal pan-cancer biomarker
due to its involvement in tumor progression and tumor immunity.
Publisher
Bentham Science Publishers Ltd.