Novel Perspectives of TSLP and RXR Signaling in Corticosteroid-Resistant Asthma: Updates on TSLP Blockers-Reference-Cited by-同舟云学术

Novel Perspectives of TSLP and RXR Signaling in Corticosteroid-Resistant Asthma: Updates on TSLP Blockers

Published:2024-02-16 Issue: Volume:31 Page:
ISSN:0929-8673
Container-title:Current Medicinal Chemistry
language:en
Short-container-title:CMC

Author:

Zhang Song¹²,Dsouza Karen³,Beeraka Narasimha M⁴⁵⁶,Liu Junqi¹²,Reshetniak Oksana⁵,PR Hemanth Vikram³⁷,Priyanka LG⁸,Greeshma M.V.⁹,Bhupalam Pradeep Kumar¹⁰,PA Mahesh⁹,Manogaran Prasath¹¹,Deka Rajashree¹²,Bannimath Gurupadayya³,Sinelnikov Mikhail Y⁵,Nikolenko Vladimir N.⁵,Bulygin Kirill⁵,Fan Ruitai¹²

Affiliation:

1. Cancer Center, The First Affiliated Hospital of Zhengzhou University,1 Jianshedong Str., Zhengzhou, 450052, China

2. Department of Radiation Oncology, The First Affiliated Hospital of Zhengzhou University, 1 Jianshedong Str., Zhengzhou, 450052, China

3. Department of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS Academy of Higher Education & Research (JSS AHER), Mysuru, Karnataka, India

4. Raghavendra Institute of Pharmaceutical Education and Research (RIPER), Anantapuramu, Chiyyedu, Andhra Pradesh 515721, India

5. I.M. Sechenov First Moscow State Medical University (Sechenov University), 8/2 Trubetskaya Street, Moscow, 119991, Russian Federation

6. Herman B. Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, 1044 W. Walnut Street, R4-168, Indianapolis, IN46202

7. Xenone Healthcare Pvt. Ltd, #318, Third Floor, US Complex, Jasola, New Delhi-110076

8. Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education & Research (JSS AHER), Mysuru, Karnataka, India

9. Department of Pulmonary Medicine, JSS Medical College & Hospital, Mysore, Karnataka, India

10. RAGHAVENDRA INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH Pharmacology and Toxicology ANANTAPUR India

11. Department of Biotechnology, Bharathiar University, Coimbatore, Tamil Nadu 641046, India

12. Animal Physiology and Biochemistry Laboratory, Department of Zoology, Gauhati University, Guwahati-781014, Assam, India

Abstract

Abstract: Previous studies described that asthma patients who received corticosteroid therapy have been constrained by the corticosteroid resistance subsequently fostered to severe refractory asthma. In this review, we discussed the implications of TSLP, RXR, the role of STAT5-activating cytokines, and IL-33/NH-cell signaling pathways, and recent clinical evidence on TSLP blockers in steroid-resistant asthma. We have searched several public databases such as Pubmed, Scopus, and Relemed and obtained information pertinent to the TSLP, RXR, TSLP blockers, the STAT5-activating cytokines, and IL-33. We discussed the multiple cell signaling mechanisms underlying steroid resistance. Blocking the TSLP and other key signaling molecules like STAT5 can retrieve the sensitivity of natural helper-cells to corticosteroids. RXR derivatives treatment can modulate the activity of TSLP, which further modulates steroid resistance in severe asthmatic patients and in patients with refractory asthma. We discussed the steroid-resistance mediated by the Th2 cells and Th2-driven eosinophilia upon corticosteroid intake. Thus, this review will be beneficial for clinicians and molecular biologists to explore the inflammatory pathways associated with refractory asthma conditions and develop novel therapies against corticosteroid-resistant asthma.

Publisher

Bentham Science Publishers Ltd.