Toxic Effects of Methamphetamine on Reproductive Systems, Embryo Development, and Newborns: An Evidence-Based Review-Reference-Cited by-同舟云学术

Toxic Effects of Methamphetamine on Reproductive Systems, Embryo Development, and Newborns: An Evidence-Based Review

Published:2024-06-12 Issue: Volume:31 Page:
ISSN:0929-8673
Container-title:Current Medicinal Chemistry
language:en
Short-container-title:CMC

Author:

Chen Qianqian¹,Wang Lan²,Zhang Jinlong¹,Cheng Junzhe³,Lin Jiang¹,Peng Yilin¹,Liu Yuhang¹,Zhang Changquan¹,Yan Jie¹,Niu Shuliang¹⁴

Affiliation:

1. Department of Forensic Science, School of Basic Medical Science, Central South University, Changsha, Hunan410013, China

2. Department of Anatomy, School of Basic Medical Science, Central South University, Changsha, Hunan410013, China

3. Clinical Medicine Eight-Year Program, Xiangya School of Medicine, Central South University, Changsha, Hunan, China

4. Department of Anatomy, School of Basic Medical Science, Xinjiang Medical University, Urumqi, China

Abstract

Abstract: Methamphetamine (METH), an amphetamine-type stimulant, has been extensively abused globally in the past decades. METH use causes great harm to the major systems of the human body. Specifically, METH has a negative impact on the hypothalamic- pituitary-testicular axis, testicular structure, sperm function, ovarian folliculogenesis, oocyte quality, embryo development, and newborns. However, the mechanisms underlying these toxic effects have not yet been fully described. This study reviews the evidence concerning the impact of METH on male and female reproduction in the context of the testis, sperm, ovaries, oocytes, reproductive hormones, embryo development, and newborns, discussing the potential pathophysiological mechanisms in the reproductive toxicity induced by METH.

Publisher

Bentham Science Publishers Ltd.