Affiliation:
1. Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, International Joint
Laboratory for Arteriosclerotic Disease Research of Hunan Province, University of South China, Hengyang,
China, 421001
Abstract
Abstract:
HuR (Human antigen R) is an RNA binding protein (RBP) that specifically
binds to certain RNA sequences, influencing post-transcriptional regulation. HuR is primarily
involved in tumor regulation, as well as cell growth, proliferation, inflammation,
and angiogenesis. HuR is implicated in endothelial activation, smooth muscle proliferation,
inflammatory response, macrophage apoptosis, lipid regulation, and autophagy,
playing a crucial regulatory role in atherosclerosis. Accumulating evidence suggests that
HuR has dual roles in AS. On the one hand, HuR expedites the development of AS by facilitating
endothelial activation, smooth muscle proliferation, and inflammation. On the
contrary, it exerts beneficial effects by reducing macrophage apoptosis, regulating lipid
efflux, and increasing autophagy. In this review, we aim to provide a comprehensive
summary of the role of HuR in the development of AS by examining its involvement in
cellular mechanisms, inflammation, autophagy, and apoptosis. Additionally, we discuss
the mechanisms of drugs that target HuR, with the goal of offering new perspectives for
the treatment of AS.
Publisher
Bentham Science Publishers Ltd.
Cited by
1 articles.
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