The Regulatory Effect of Vitamin D on Pancreatic Beta Cell Secretion
in Patients with Type 2 Diabetes
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Published:2024-08-07
Issue:
Volume:31
Page:
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ISSN:0929-8673
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Container-title:Current Medicinal Chemistry
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language:en
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Short-container-title:CMC
Author:
He Lian-Ping1,
Li Cui-Ping1,
Liu Chang-Wei1,
Gu Wei1
Affiliation:
1. School of medicine, Taizhou University, Jiaojiang, 318000, Zhejiang, China
Abstract
Increasing evidence suggests that vitamin D is one of the causes of accelerated
development of Insulin Resistance (IR) and islet cell secret dysfunction. Numerous
studies have shown that vitamin D can reduce inflammation, activate the transcription of
the insulin receptors and related genes, and increase insulin-mediated glucose transport,
thereby reducing IR. This article reviews the molecular mechanisms related to vitamin
D deficiency and pancreatic β-cell dysfunction in patients with Type 2 Diabetes (T2D).
Publisher
Bentham Science Publishers Ltd.