Affiliation:
1. Institute of Pharmaceutical Research, GLA University, Mathura, Uttar Pradesh, India
2. Moradabad Educational Trust
Group of Institutions Faculty of Pharmacy, Moradabad, Uttar Pradesh, India
Abstract
Background:
Diosmetin is an O-methylated flavone and the aglycone part of the
flavonoid glycosides diosmin that occurs naturally in citrus fruits. Pharmacologically, diosmetin is
reported to exhibit anticancer, antimicrobial, antioxidant, oestrogenic, and anti-inflammatory activities.
Objective:
This comprehensive review was aimed to critically explore diverse pharmacological activities
exhibited by diosmetin. Along with that, this review can also identify potential research areas
with an elucidation of the multifactorial underlying signaling mechanism of action of diosmetin
in different diseases.
Methods:
A comprehensive collection of evidence and insights was obtained from scientific journals
and books from physical libraries and electronic platforms like Google Scholar and PubMed.
The time frame selected was from year 1992 to July 2023.
Results:
The review delves into diosmetin's impact on cellular signaling pathways and its potential
in various diseases. Due to its ability to modulate signaling pathways and reduce oxidative
stress, it can be suggested as a potential versatile therapeutic agent for mitigating oxidative stressassociated
pathogenesis.
Conclusion:
The amalgamation of the review underscores diosmetin's promising role as a multifaceted
therapeutic agent, highlighting its potential for drug development and clinical applications.
Publisher
Bentham Science Publishers Ltd.