Pharmacological activity and mechanisms of action of terpenoids from Laurus nobilis L-Reference-Cited by-同舟云学术

Pharmacological activity and mechanisms of action of terpenoids from Laurus nobilis L

Published:2022-12-08 Issue: Volume:13 Page:
ISSN:2210-3155
Container-title:The Natural Products Journal
language:en
Short-container-title:NPJ

Author:

Kamdem Boniface Pone¹²^ORCID,Le Doux Kamto Eutrophe³^ORCID,Soh Désiré⁴,Pegnyemb Dieudonné Emmanuel³^ORCID,Zingue Stéphane⁵⁶^ORCID,Paumo Hugues Kamdem⁷^ORCID,Katata-Seru Lebogang Maureen⁷^ORCID,Abou Aboubakar⁸,Rosinah Montsho Maiyane⁹,Mbah James Ajeck¹⁰,Boyom Fabrice Fekam²

Affiliation:

1. Department of Pharmacy, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil

2. Laboratory for Phytobiochemistry and Medicinal Plants Study, Department of Biochemistry, Faculty of Science, University of Yaoundé 1; P.O. Box 812, Yaoundé-Cameroon.

3. Department of Organic Chemistry, Faculty of Science, University of Yaounde 1, P.O. Box 812, Yaounde, Cameroon

4. Department of Chemistry, Higher Teacher Training College, University of Bamenda, P.O Box 39 Bambili, Cameroon

5. Department of Medical and Biomedical Engineering, Higher Technical Teachers’ Training College, University of Yaounde 1, P.O. Box 886 Ebolowa, Cameroon

6. Department of Life and Earth Sciences, Higher Teachers’ Training College, University of Maroua, P.O. Box 55 Maroua, Cameroon

7. Department of Chemistry and Materials Science Innovation & Modelling Research Focus Area, School of Physical and Chemical Sciences, Faculty of Natural and Agricultural Sciences, North-West University, Private Bag X2046, Mmabatho 2735, South Africa

8. Department of Biochemistry, Faculty of Science, University of Ngaoundere, P.O. Box. 454 Ngaoundere, Cameroon

9. South African Health Products Regulatory Authority (SAHPRA), Loftus Park, building A, Building A, 402 Kirkness St, Arcadia, 0083, Pretoria, South Africa

10. University of Buea, Faculty of Science, Department of Chemistry, Box 63 Buea, Cameroon.

Abstract

Background: Native to the Southern Mediterranean region, Laurus nobilis L. (Family Lauraceae) is an evergreen shrub or tree found in warm climate regions with high rainfall. The leaves and essential oil of this plant have been widely used as condiments, spices, and flavoring agents in the culinary and food industries. The whole plant is also used for the traditional treatment of various diseases, including cough, asthma, hemorrhoids, rheumatic pain, diarrhea, intestinal, and cardiac diseases. Previous phytochemical investigation of this plant demonstrated the presence of a variety of secondary metabolites, especially terpenoids. Aim: The present study aims to critically analyze comprehensive literature on the pharmacological activity and mechanisms of action of terpenoids from Laurus nobilis L. Methods: The available information on the pharmacological activity of terpenoids from L. nobilis L. was obtained from textbooks, theses, as well as published articles through a variety of libraries and electronic databases. Results: The present study demonstrated that L. nobilis is rich in terpenoids, with more than 200 entities identified in reported studies. Terpenoids from L. nobilis have shown a wide range of pharmacological activities, including anti-inflammatory, antidiabetic, antifungal, antibacterial, immunomodulatory, anticonvulsant, antioxidant and cytotoxic activities. The mechanisms of action of most of these terpenoids included the imbalance of the ionic permeability of the cell membrane (anti-inflammatory and antimicrobial activities), modulation of the effects of gamma-aminobutyric acid (GABA)nergic neurotransmission (anticonvulsant activity), and the inhibition of inflammatory responses, prevention of metastasis, and induction of apoptosis (cytotoxic effect), among others. Conclusion: Referring to in vitro studies, terpenoids of L. nobilis L. have shown a variety of biological activities. However, more cytotoxic and in vivo studies and detailed mechanisms of action of the bioactive terpenoids are recommended.

Publisher

Bentham Science Publishers Ltd.

Subject

Complementary and alternative medicine,Drug Discovery