Xanthoangelol Isolated from Angelica keiskei Roots Prevents Dextran Sulfate Sodium-Treated Colitis in Mice
-
Published:2020-09-11
Issue:5
Volume:10
Page:655-663
-
ISSN:2210-3155
-
Container-title:The Natural Products Journal
-
language:en
-
Short-container-title:NPJ
Author:
Kimura Yoshiyuki1ORCID, Baba Kimye2
Affiliation:
1. Department of Functional Biomedicine, Ehime University Graduate School of Medicine, Shitsukawa, Toon City Ehime 791-0295, Japan 2. Department of Pharmacognosy, Osaka University of Pharmaceutical Sciences, Takatsuki City, Osaka 569-1094, Japan
Abstract
Background:
The therapeutic effects of a number of natural products on Inflammatory
Bowel Disease (IBD) have recently been examined in detail. The whole herb and roots of Angelica
keiskei (Umblliferae) have traditionally been used as a diuretic, to treat gastrointestinal diseases such
as gastric ulcers and diarrhea in Japan.
Objectives:
The present study was performed to investigate the effects of xanthoangelol, a major
chalcone of Angelica keiskei roots, on diarrhea and inflammation in the large intestine of IBD model
mice.
Methods:
Xanthoangelol (10 & 25 mg/kg) was orally administered to mice with 3% Dextran Sulfate
Sodium (DSS)-induced colitis. Blood samples were collected during the experimental period, subjected
to a full blood count test, and colonic cytokine and chemokine levels were measured.
Results:
Xanthoangelol (25 mg/kg) reduced the Disease Activity Index (DAI) of colitis. It also attenuated
DSS-induced reductions in red blood cell and platelet counts as well as Hb and Ht levels. A
histological examination of the colon using direct fast scarlet staining showed that xanthoangelol
prevented DSS-induced mucosal ulceration and eosinophil infiltration. Xanthoangelol also reduced
DSS-induced increases in colonic MCP-1, IL-1β, and TNF-α levels.
Conclusions:
Xanthoangelol reduced DSS-induced increases in colonic IL-1β, TNF-α, and MCP-1
levels and prevented eosinophil infiltration, which supports its potential as a treatment for IBD.
Funder
Japan Society for the Promotion of Science
Publisher
Bentham Science Publishers Ltd.
Subject
Complementary and alternative medicine,Drug Discovery
Reference37 articles.
1. Oh kura,N.; Ohnishi,K.; Tanigichi,M.; Na-kayama,A.; Usuba,Y.; Fujita,M.; Fujii,A.; Ishibashi,K.; Baba,K.; Atsuni, G. Anti-platelet effects of chalcones from Angelica keiskei Koidzumi (Ashi-taba) in vivo. Die Pharmazie. 2016,71,6651-6654 2. Kim,A.; Lim, J.W.; Kim,H.; Kim, H. Supplementation with An-gelica keiskei inhibits expression of inflammatory mediators in the gastric mucosa of Helicobacter pylori-infected mice. Nutr. Res. 2016,36(5),488-497. http://dx.doi.org/10.1016/j.nutres.2015.12.017 PMID: 27101766 3. Kil, Y.S.; Pham, S.T.; Seo, E.K.; Jafari, M. Angelica keiskei, an emerging medicinal herb with various bioactive constituents and biological activities. Arch. Pharm. Res. 2017,40(6),655-675. http://dx.doi.org/10.1007/s12272-017-0892-3 PMID: 28439780 4. Oh kura,N.; Atsumi,G.; Ohnishi,K.; Baba,K.; Taniguchi, M. Possible antithrombotic effects of Angelica keiskei (Ashitaba) . Pharmazie. 2018,73(6),315-317. PMID: 29880082 5. Ohta,M.; Fujinami,A.; Oishi,K.; Kobayashi,N.; Ohnishi,K.; Oh-kura, N. Ashitba(Angelica keiskei) exudate prevents increases in plasminogen activator inhibitor-1 induced by obesity in Tsumura Suzu ki obese diabetic mice, J. Diet. Suppl. 2019,16(3),331-344. http://dx.doi.org/10.1080/19390211.2018.1458366 PMID: 29708806
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
|
|