Affiliation:
1. Central Institute of Psychiatry, Ranchi, India
2. Centre for Child and Adolescent Psychiatry, Central
Institute of Psychiatry, Ranchi, India
3. College of Medicine, Shaqra University, Shaqra, Al Riyadh, KSA
Abstract
Background:
Hunger hormones, including ghrelin and leptin, are
associated with appetitive behaviors in various psychiatric disorders. Biochemical
and hormonal status in disruptive mood dysregulation disorder (DMDD) in
adolescents is largely unexplored.
Objectives:
The study aimed to assess levels of leptin and ghrelin and find their
association with lipid profiles in adolescents with DMDD.
Methods:
Twenty adolescents with a DSM 5 diagnosis of DMDD with age and
gender-matched 19 healthy controls were recruited, followed by clinical
assessment. They were assessed for leptin, ghrelin, and lipid profiles, respectively.
Results:
Adolescents with DMDD were comparable in age, education, family
income, domicile status, psychiatric illness in the family, and body mass index
(BMI) with matched controls. There was no difference in mean lipid profile and
ghrelin in both groups. However, the DMDD group had a statistically significant
higher mean level of leptin as compared to the control group (t=1.84, p < 0.05). As
measured by the Modified Overt Aggression Scale in DMDD, aggression showed a
significant positive correlation with lipid profile measures.
Conclusion:
Adolescents with DMDD have elevated serum leptin levels. Further
research is needed to confirm this finding.
Publisher
Bentham Science Publishers Ltd.
Subject
Psychiatry and Mental health,Pediatrics, Perinatology, and Child Health