Affiliation:
1. Department of Neurosurgery, Medical School, Democritus University of Thrace, Alexandroupolis, Greece
2. Department of Radiation Oncology, University Hospital Queen Giovanna, Sofia, Bulgaria
Abstract
Background:
Turcot’s syndrome (TS) is a rare disease with known incidence of about
1-2 cases per year. It is, however, linked to high mortality due to the brain cancer. And because of
this, we propose recommendations, aimed at preventing the mortality of the patients and to minimize
the risk of undiagnosed Turcot’s syndrome.
Methods:
The authors collected the worldwide published data on TS, from the year of its definition
till 2018, all of which was published on the search engines, such as Medline, Medknow, Cohraine
and Wiley.
Results:
We included 97 patients, 57 from which are females and 40 males with median age of 22
years. The most common type of cancer is medulloblastoma, followed by glioblastoma and astrocytoma.
We further divided the patients into two categories based on the first symptom of the disease
and we made an algorithm of approaching these patients.
Conclusion:
TS is a disease that affects mostly members of families with multiple genetic mutations
and types of cancers. And because of the unknown mechanisms of inheritance, it is useful to
establish guidelines for the approach of those patients, in order to minimize the high mortality
rate.
Publisher
Bentham Science Publishers Ltd.
Subject
Cancer Research,Oncology,Molecular Medicine
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