6-(Arylaminomethyl) Isoquinolines as Enzyme Inhibitors and Their Preparation: A Patent Highlight of Factor XIIa Inhibitors
Author:
Affiliation:
1. Division of Basic Pharmaceutical Sciences, College of Pharmacy, Xavier University of Louisiana, New Orleans LA 70125, USA
Abstract
Funder
NIGMS of the National Institute of Health
Publisher
Bentham Science Publishers Ltd.
Subject
Cardiology and Cardiovascular Medicine,Pharmacology,Hematology
Reference69 articles.
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2. Pathak M.; Manna R.; Li C.; Kaira B.G.; Hamad B.K.; Belviso B.D.; Bonturi C.R.; Dreveny I.; Fischer P.M.; Dekker L.V.; Oliva M.L.V.; Emsley J.; Crystal structures of the recombinant β-factor XIIa protease with bound Thr-Arg and Pro-Arg substrate mimetics. Acta Crystallogr D Struct Biol 2019,75(6),578-591
3. Dementiev A.; Silva A.; Yee C.; Li Z.; Flavin M.T.; Sham H.; Partridge J.R.; Structures of human plasma β–factor XIIa cocrystallized with potent inhibitors. Blood Adv 2018,2(5),549-558
4. Fischer P.M.; Design of small-molecule active-site inhibitors of the S1A family proteases as procoagulant and anticoagulant drugs. J Med Chem 2018,61(9),3799-3822
5. Hamad B.K.; Pathak M.; Manna R.; Fischer P.M.; Emsley J.; Dekker L.V.; Assessment of the protein interaction between coagulation factor XII and corn trypsin inhibitor by molecular docking and biochemical validation. J Thromb Haemost 2017,15(9),1818-1828
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1. New Triazole-Based Potent Inhibitors of Human Factor XIIa as Anticoagulants;ACS Omega;2024-02-22
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