Affiliation:
1. Department of biology, Moulay Ismail University of Meknes, Errachidia, Morocco
Abstract
Aims:
The study aimed to study the antihypertensive activity of Laurus nobilis.
Background:
Laurus nobilis L. is used to treat hypertension in Morocco.
Objective:
The study was designed to investigate the effect of the aqueous extract leaves of Laurus
nobilis (AELN) on blood pressure.
Materials and Methods:
The antihypertensive and vasorelaxant activities of AELN were pharmacologically
investigated in normotensive and L-NAME-induced hypertensive rats. Thereafter,
blood pressure was evaluated, and the ex-vivo vasorelaxant activity of this extract was performed.
Results:
A considerable decrease in blood pressure parameters were observed in L-NAMEinduced
hypertensive rats treated with AELN. The extract induced a vasorelaxant effect on the
aorta precontracted with epinephrine or KCl by inhibiting extracellular Ca2+ entry.
Conclusion:
The study demonstrates that Laurus nobilis aqueous extract exhibits potent antihypertensive
and vasorelaxant activities via inhibiting Ca2+ entry.
Funder
CNRST, Centre National pour la Recherche Scientifique et Technique
Publisher
Bentham Science Publishers Ltd.
Subject
Cardiology and Cardiovascular Medicine,Pharmacology,Hematology
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