Affiliation:
1. Department of Ethnopharmaology and Pharmacognosy, Faculty of Sciences and Techniques Errachidia, Moulay Ismail University of Meknes, BP 509, Boutalamine 52000, Errachidia,Morocco
Abstract
Aims:
The study aimed to evaluate the antihyperlipidemic and antioxidant activities of
Matricaria pubescens.
Background:
Matricaria pubescens (Desf.) Shultz belongs to Asteraceae family and it is commonly
used traditionally for handling diabetes mellitus.
Objective:
The objective of this study was to assess the antioxidant activity of Matricaria pubescens
(Desf.) Shultz and its effect on lipid and lipoprotein profile in normal and streptozotocin-induced diabetic
rats.
Methods:
The effect of repeated (7 days of treatment) oral administration of the aqueous extracts of
aerial part of Matricaria pubescens (MPAE) at a dose of 40 mg/kg on lipid and lipoprotein profile
was examined in normal and streptozotocin-induced diabetic rats. Furthermore, a preliminary phytochemical
screening and the quantification of phenolic, flavonoid and tannin contents as well as the
antioxidant activity using two methods (FRAP and ABTS) were carried out.
Results:
MPAE demonstrated a potent antidyslipidemic effect in diabetic rats by reducing serum levels
of triglycerides, total cholesterol and Low-Density Lipoprotein (LDL). In addition, the results
showed that the extract is rich in several phytochemical compounds and revealed an important antioxidant
activity.
Conclusion:
In summary, this study proved that Matricaria pubescens (Desf.) Shultz. has a
favorable effect on diabetic dyslipidemia.
Publisher
Bentham Science Publishers Ltd.
Subject
Cardiology and Cardiovascular Medicine,Pharmacology,Hematology
Cited by
5 articles.
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