Tertiary Nanosystem Composed of Graphene Quantum Dots, Levofloxacin and Silver Nitrate for Microbiological Control

Author:

Santos-Oliveira Ralph12,Vieira Thamires Oliveira1,Ricci-Junior Eduardo3,de Barros Aline Oiveira da Silva1,Rebelo Alencar Luciana Magalhães4,Ferreira Marcia Regina Spuri5,de Jesus Andreoli Pinto Terezinha5,de Holanda Saboya Souza Diego6

Affiliation:

1. Brazilian Nuclear Energy Commission, Nuclear Engineering Institute, Laboratory of Nanoradiopharmacy and Synthesis of New Radiopharmaceuticals, Rio de Janeiro 21941906, Brazil

2. Zona Oeste State University, Laboratory of Nanoradiopharmaceuticals, Rio de Janeiro 23070200, Brazil;

3. Federal University of Rio de Janeiro, College of Pharmacy, Galenical Development Laboratory, Rio de Janeiro 21941900, Brazil

4. Federal University of Maranhão, Department of Physics, Maranhão 65080805, Brazil

5. Department of Pharmacy, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo 05508-000, Brazil

6. Institute of Macromolecules Professor Eloísa Mano (IMA), Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 21941900, Brazil

Abstract

Background: Infectious diseases have the highest mortality rate in the world and these numbers are associated with scarce and/or ineffective diagnosis and bacterial resistance. Currently, with the development of new pharmaceutical formulations, nanotechnology is gaining prominence. Methods: Nanomicelles were produced by ultrasonication. The particle size and shape were evaluated by scanning electron microscopy and confirmed by dynamic light scattering, also thermogravimetric analysis was performed to evaluate the thermal stability. Finally, antibacterial activity has been performed. Results: The results showed that a rod-shaped nanosystem, with 316.1 nm and PDI of 0.243 was formed. The nanosystem was efficient against Staphylococcus aureus, Pseudomonas aeruginosa, and Bacillus subtilis subsp. spizizenii with MIC inferior to 0.98 and a synergistic effect between silver graphene quantum dots and levofloxacin was observed. Conclusion: The nanosystem produced may rise as a promising agent against the bacterial threat, especially regarding bacterial resistance.

Funder

Carlos Chagas Filho Foundation for Research Support of Rio de Janeiro State

Infraestrutura e Pesquisa na UEZO e UERJ

Conselho Nacional de Desenvolvimento Científico e Tecnológico, CNPq

Publisher

Bentham Science Publishers Ltd.

Subject

Pharmaceutical Science,Biomedical Engineering

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