Hybrid Magnetic Nanostructures For Cancer Diagnosis And Therapy
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Published:2019-05-08
Issue:1
Volume:19
Page:6-16
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ISSN:1871-5206
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Container-title:Anti-Cancer Agents in Medicinal Chemistry
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language:en
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Short-container-title:ACAMC
Author:
Ardelean Ioana L.1, Ficai Denisa1, Sonmez Maria2, Oprea Ovidiu1, Nechifor Gheorghe1, Andronescu Ecaterina1, Ficai Anton1, Titu Mihail A.3
Affiliation:
1. University POLITEHNICA of Bucharest, Faculty of Applied Chemistry and Material Science; 1-7 Polizu Str., 011061 Bucharest, Romania 2. Leather and Footwear Research Institute, Department of Rubber, 93 Ion Minulescu street, 031215, Bucharest, Romania 3. Romania
Abstract
Cancer is the second disease in the world from the point of view of mortality. The conventional
routes of treatment were found to be not sufficient and thus alternative ways are imposed. The use of hybrid,
magnetic nanostructures is a promising way for simultaneous targeted diagnosis and treatment of various types
of cancer. For this reason, the development of core@shell structures was found to be an efficient way to develop
stable, biocompatible, non-toxic carriers with shell-dependent internalization capacity in cancer cells. So, the
multicomponent approach can be the most suitable way to assure the multifunctionality of these nanostructures
to achieve the desired/necessary properties. The in vivo stability is mostly assured by the coating of the magnetic
core with various polymers (including polyethylene glycol, silica etc.), while the targeting capacity is mostly
assured by the decoration of these nanostructures with folic acid. Unfortunately, there are also some limitations
related to the multilayered approach. For instance, the increasing of the thickness of layers leads to a decrease
the magnetic properties, (hyperthermia and guiding ability in the magnetic field, for instance), the outer
shell should contain the targeting molecules (as well as the agents helping the internalization into the cancer
cells), etc.
Funder
European Commission
Publisher
Bentham Science Publishers Ltd.
Subject
Cancer Research,Pharmacology,Molecular Medicine
Reference140 articles.
1. Kolhatkar AG, Jamison AC, Litvinov D, Willson RC, Lee TR. Int J Mol Sci, Tuning the magnetic properties of nanoparticles.,, 2013, 14,, 15977-16009, 2. Jordan A, Scholz R, Wust P, Fahling H, Felix R. J Magn Mater, Magnetic Fluid Hyperthermia (MFH): Cancer treatment with AC magnetic field induced excitation of biocompatible superparamagnetic nanoparticles.,, 1999, 201,, 413-419, 3. Vallejo-Fernandez G, Whear O, Roca AG, Hussain S, Timmis J, Patel V, O’Grady K. J Phys D Appl Phys, Mechanisms of hyperthermia in magnetic nanoparticles.,, 2013, 46,, 312001-, 4. Frey NA, Peng S, Cheng K, Sun SH. Chem Soc Rev, Magnetic nanoparticles: Synthesis, functionalization, and applications in bioimaging and magnetic energy storage.,, 2009, 38,, 2532-2542, 5. Horak D, Rittich B, Spanova A, Benes MJ. Polymer, Magnetic microparticulate carriers with immobilized selective ligands in DNA diagnostics.,, 2005, 46,, 1245-1255,
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