Metal Complexes of Natural Product Like-compounds with Antitumor Activity
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Published:2019-05-08
Issue:1
Volume:19
Page:48-65
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ISSN:1871-5206
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Container-title:Anti-Cancer Agents in Medicinal Chemistry
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language:en
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Short-container-title:ACAMC
Author:
Heras Beatriz L.1, Amesty Ángel2, Estévez-Braun Ana2, Hortelano Sonsoles3
Affiliation:
1. Departamento de Farmacologia. Facultad de Farmacia, Universidad Complutense de Madrid (UCM), Madrid, Spain 2. Departamento de Quimica Organica, Instituto Universitario de Bio-Organica Antonio Gonzalez, Universidad de La Laguna. Avda. Astrofisico Fco. Sanchez 2. 38206. La Laguna, Tenerife, Spain 3. Unidad de Terapias Farmacologicas. Area de Genetica Humana. Instituto de Investigacion de Enfermedades Raras (IIER), Instituto de Salud Carlos III, Madrid, Spain
Abstract
Cancer continues to be one of the major causes of death worldwide. Despite many advances in the
understanding of this complex disease, new approaches are needed to improve the efficacy of current therapeutic
treatments against aggressive tumors. Natural products are one of the most consistently successful sources of drug
leads. In recent decades, research activity into the clinical potential of this class of compounds in cancer has
increased. Furthermore, a highly promising field is the use of metals and their complexes in the design and
development of metal-based drugs for the treatment of cancer. Metal complexes offer unique opportunities due to
their ability to alter pharmacology, improving the efficacy and/or reducing the negative side effects of drug
molecules. In addition, transition metals as copper, iron, and manganese, among others, can interact with active
sites of enzymes, playing important roles in multiple biological processes. Thus, these complexes not only possess
higher activities but also reach their targets more efficiently. This review article highlights recent advances on the
emerging and expanding field of metal-based drugs. The emphasis is on new therapeutic strategies consisting of
metal complexes with natural product like-compounds as a starting point for the rational design of new antitumor
agents.
Publisher
Bentham Science Publishers Ltd.
Subject
Cancer Research,Pharmacology,Molecular Medicine
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