Affiliation:
1. Department of Normal and Pathological Physiology, National Research Mordovia State University,
Bolshevitskaya Street, 68, Saransk, Rep. Mordovia, 430005, Russia
Abstract
Abstract:
Myocardial cell injury and following sequelae are the primary reasons for
death globally. Unfortunately, myocardiocytes in adults have limited regeneration
capacity. Therefore, the generation of neo myocardiocytes from non-myocardial cells is
a surrogate strategy. Transcription factors (TFs) can be recruited to achieve this
tremendous goal. Transcriptomic analyses have suggested that GATA, Mef2c, and Tbx5
(GMT cocktail) are master TFs to transdifferentiate/reprogram cell linage of fibroblasts,
somatic cells, mesodermal cells into myocardiocytes. However, adding MESP1,
MYOCD, ESRRG, and ZFPM2 TFs induces the generation of more efficient and
physiomorphological features for induced myocardiocytes. Moreover, the same cocktail
of transcription factors can induce the proliferation and differentiation of
induced/pluripotent stem cells into myocardial cells. Amelioration of impaired myocardial
cells involves the activation of healing transcription factors, which are induced by
inflammation mediators; IL6, tumor growth factor β, and IL22. Transcription factors
regulate the cellular and subcellular physiology of myocardiocytes to include mitotic cell
cycling regulation, karyokinesis and cytokinesis, hypertrophic growth, adult sarcomeric
contractile protein gene expression, fatty acid metabolism, and mitochondrial biogenesis
and maturation. Cell therapy by transcription factors can be applied to cardiogenesis and
ameliorating impaired cardiocytes. Transcription factors are the cornerstone in cell
differentiation.
Publisher
Bentham Science Publishers Ltd.
Subject
Molecular Biology,Molecular Medicine,General Medicine,Biochemistry
Cited by
6 articles.
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