Are Monocyte, %M and WBC Biomarkers in the First Trimester Screening Test?

Abstract

Background: Differences in free beta HCG and PAPP-A values, which are among the biochemical parameters in the double screening test, is frequently used for pregnancy follow-up, allow aneuploidy and triploidy risk to be determined. In recent studies, it’s suggested that the modified hemogram indices have gained importance as a marker in the prognosis of diseases. Objective: In this study, we aimed to determine the hematological parameters, which are routinely applied in the first trimester of pregnancy, have any value in predicting the risk increase in the double screening test and in early diagnosis. Method: Pregnant women who conceived spontaneously and had double screening tests were included in the study. CBC results that were studied together with the first trimester screening test were reported. The patients were divided into two groups according to the results of the screening test as the combined risk ratio. Results: The mean age was found to be significantly higher in the high-risk group than in the low-risk group. Monocyte, % M and WBC values were significantly lower in the high-risk group (0,483±0,140, 5,58±1,44 and 8,75±2,12 , respectively). There was no significant difference in NLR and PLR values compared between the groups. MPV values were lower and PAPP-A, PAPP-A MoM values were significantly lower in high-risk group compared to the low-risk group. Conclusion: The findings support low Monocyte, % M and WBC values as a potential marker for the identification of the high risk pregnancy in otherwise healthy pregnant women. The results indicate that CBC parametres commonly used in pregnancy can be used to predict the prognosis.