Affiliation:
1. Federal University of Goias, Faculty of Pharmacy. 240 st., Leste Universitario Sector, Goiania, Goias State, ZIP: 74605-170, Brazil
Abstract
Background:
Over-the-counter hepatoprotective nutraceuticals are highly commercialized
preparations worldwide. However, their alleged antioxidant capacity and health benefits are
still not fully understood.
Objective:
This work showcased the first investigation of the redox behavior of hepatoprotective
nutraceuticals by spectrophotometric and electrochemical approaches.
Methods:
The samples were segregated into two groups, namely: A, B, and C based on isolated
compounds (IC); and D, E and F based on standardized herbal extracts (SHE).
Results:
Results evidenced that IC showcase similar response and distinctions could be attributed
to varying concentrations of choline. In SHE, the slopes showcased superimposition due to the presence
of Peumus boldus. The electrochemical assays showcased that samples A and C exhibited a
single anodic peak at Ep1a ≈ +0.7 V, which could be attributed to the oxidation of methionine;
while samples D, E and F, showcased two anodic peaks at Ep1a ≈ +0.35V and Ep2a ≈ +0.7 V,
suggesting the oxidation of phenolic and amine moieties respectively. Furthermore, the first two
principal components explained 84.8% of all variance in the model, thereby suggesting statistical
reproducibility.
Conclusion:
This work showcased the first investigation of the redox behavior of hepatoprotective
nutraceuticals, thereby shedding light on their antioxidant capacity and physical-chemistry.
Publisher
Bentham Science Publishers Ltd.
Reference45 articles.
1. Sharma J.; Gairola S.; Gaur R.D.; Painuli R.M.; The treatment of jaundice with medicinal plants in indigenous communities of the Sub-Himalayan region of Uttarakhand, India. J Ethnopharmacol 2012,143(1),262-291
2. Speroni E.; Cervellati R.; Govoni P.; Guizzardi S.; Renzulli C.; Guerra M.C.; Efficacy of different Cynara scolymus preparations on liver complaints. J Ethnopharmacol 2003,86(2-3),203-211
3. Pradhan S.C.; Girish C.; Hepatoprotective herbal drug, silymarin from experimental pharmacology to clinical medicine. Indian J Med Res 2006,124(5),491-504
4. Tedesco D.; Tava A.; Galletti S.; Tameni M.; Varisco G.; Costa A.; Steidler S.; Effects of silymarin, a natural hepatoprotector, in periparturient dairy cows. J Dairy Sci 2004,87(7),2239-2247
5. Mohamed Saleem TS; Madhusudhana Chetty S; Ramkanth S; Rajan VST; Mahesh Kumar K; Gauthaman K; Hepatoprotective herbs - a review. Int J Res Pharm Sci 2010
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