Affiliation:
1. Department of Pathophysiology, Key Lab of Neurological Disorder of Education, Ministry, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China
Abstract
DNA double-strand breaks (DSBs) are common events that were recognized as one of
the most toxic lesions in eukaryotic cells. DSBs are widely involved in many physiological processes
such as V(D)J recombination, meiotic recombination, DNA replication and transcription.
Deregulation of DSBs has been reported in multiple diseases in human beings, such as the neurodegenerative
diseases, with which the underlying mechanisms are needed to be illustrated. Here, we
reviewed the recent insights into the dysfunction of DSB formation and repair, contributing to the
pathogenesis of neurodegenerative disorders including Alzheimer’s disease (AD), amyotrophic
lateral sclerosis (ALS), Huntington’s disease (HD) and ataxia telangiectasia (A-T).
Funder
National Natural Science Foundation of China
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmacology (medical),Psychiatry and Mental health,Neurology (clinical),Neurology,Pharmacology,General Medicine
Cited by
18 articles.
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