Affiliation:
1. Université de Poitiers, INSERM U-1084, LNEC, F-86000 Poitiers, France
Abstract
:
Neuropeptide Y (NPY), a 36 amino acid peptide, is widely expressed in the mammalian brain.
Changes in NPY levels in different brain regions and plasma have been described in several
neurodegenerative diseases, including Alzheimer’s disease, Parkinson's disease, Huntington’s
disease, Amyotrophic Lateral Sclerosis, and Machado-Joseph disease. The changes in NPY levels
may reflect the attempt to set up an endogenous neuroprotective mechanism to counteract the
degenerative process. Accumulating evidence indicates that NPY can function as an anti-
apoptotic, anti-inflammatory, and pro-phagocytic agent, which may be used effectively to halt or
to slow down the progression of the disease. In this review, we will focus on the neuroprotective
roles of NPY in several neuropathological conditions, with a particular focus on the anti-
inflammatory properties of NPY.
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmacology (medical),Psychiatry and Mental health,Clinical Neurology,Neurology,Pharmacology,General Medicine
Cited by
23 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献