The Combined Effect of Curcumin and Crocin on the Reduction of Inflammatory Responses in Arthritic Rats-Reference-Cited by-同舟云学术

The Combined Effect of Curcumin and Crocin on the Reduction of Inflammatory Responses in Arthritic Rats

Published:2023-04-09 Issue: Volume:30 Page:
ISSN:0929-8673
Container-title:Current Medicinal Chemistry
language:en
Short-container-title:CMC

Author:

Sahebkar Amirhossein¹²³,Rashidi Khodabakhsh⁴,Korani Mitra⁴,Nemati Houshang⁵,Shahraki Raheleh⁶,Korani Shahla⁴,Abbasifard Mitra⁷⁸,Majeed Muhammed⁹,Jamialahmadi Tannaz¹

Affiliation:

1. Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

2. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran

3. Department of Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

4. Research Center of Oils and Fats, Kermanshah University of Medical Sciences, Kermanshah, Iran

5. Fertility and Infertility Research Centre, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran

6. Departmant of Histology, School of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran

7. Immunology of Infectious Diseases Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran

8. Department of Internal Medicine, Ali-Ibn Abi-Talib Hospital, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran

9. Sabinsa Corporation, East Windsor, NJ, United States

Abstract

Background: The present study evaluated the anti-arthritic impact of combined crocin and curcumin on Adjuvant Induced Arthritis (AIA) in rats. Methods: The arthritis model was induced in rats by injecting Complete Freund’s adjuvant (CFA) into the right hind paw and was subsequently treated with crocin and curcumin. Evaluation of anti-arthritic activity was carried out using paw swelling, hematological parameters, biochemical parameters, inflammatory cytokines, and histopathology of rats. Results: The results showed increased paw swelling, increased serum markers levels, including CRP, RF, ALP, ALT, and AST, and inflammatory cytokines (ILlβ and TNFα) along with histology changes (cartilage and bone degradation) in arthritic rats when compared to the normal group. Crocin, curcumin and crocin + curcumin administration at different doses (especially combination at 40 mg/kg and 30 mg/kg, respectively), as well as MTX, revealed a suitable therapeutic effect on AIA rats. Moreover, both phytochemicals and their combination at different doses showed effective anti-arthritic effects owing to their anti-inflammatory effects. Conclusions: Crocin and curcumin, either alone or in combination, can be a suitable treatment modality for rheumatoid arthritis.

Publisher

Bentham Science Publishers Ltd.

Subject

Pharmacology,Molecular Medicine,Drug Discovery,Biochemistry,Organic Chemistry