Affiliation:
1. Key Laboratory of Chemistry of Plant Resources in Arid Regions，Xinjiang Technical Institute of Physics
and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, China
2. University of Chinese Academy of
Sciences, Beijing, 100049, China
Abstract
Abstract:
Vitiligo is a disease characterized by skin discoloration, and no safe and effective
drugs have been developed until now. New drug research and development are
imminent. This article reviews the research on small-molecule drugs for vitiligo from
1990 to 2021 at home and abroad. They are classified according to their structures and
mechanisms of action, including natural products and derivatives, anti-oxidative stress
drugs, immunosuppressants, prostaglandins, etc. The research on their anti-vitiligo activity,
structural modification, new dosage forms, clinical trials, and the development trend
in new anti-vitiligo drugs are reviewed, which provides important references for the development
of new drugs.
Funder
National Key R&D Program of China
West Light Foundation of the Chinese Academy of Sciences
Youth Innovation on Promotion Association, Chinese Academy of Science
Special Training Program of Natural Science Foundation of Xinjiang Autonomous Region
Natural Science Foundation of Xinjiang, China
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmacology,Molecular Medicine,Drug Discovery,Biochemistry,Organic Chemistry
Reference234 articles.
1. Ezzedine K.; Lim H.W.; Suzuki T.; Katayama I.; Hamzavi I.; Lan C.C.E.; Goh B.K.; Anbar T.; Silva de Castro C.; Lee A.Y.; Parsad D.; van Geel N.; Le Poole I.C.; Oiso N.; Benzekri L.; Spritz R.; Gauthier Y.; Hann S.K.; Picardo M.; Taieb A.; Revised classification/nomenclature of vitiligo and related issues: The Vitiligo Global Issues Consensus Conference. Pigment Cell Melanoma Res 2012,25(3),E1-E13
2. Castanedo-Cazares J.P.; Lepe V.; Moncada B.; Repigmentation of chronic vitiligo lesions by following tacrolimus plus ultraviolet-B-narrow-band. Photodermatol Photoimmunol Photomed 2003,19(1),35-36
3. Cheng A.H.; Han M.H.; Han X.; Research Progress on the pathogenesis of vitiligo. World Latest Med Info 2017,17(46),33-34
4. Ebanks J.; Wickett R.; Boissy R.; Mechanisms regulating skin pigmentation: the rise and fall of complexion coloration. Int J Mol Sci 2009,10(9),4066-4087
5. Wang L.; Liu J.; Research progress on molecular mechanism in the formation of melanin. J Xinjiang Univ 2019,36(4),468-474+499
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