An Updated Review of the Cross-talk Between MicroRNAs and Epigenetic Factors in Cancers

Author:

Dastmalchi Narges1ORCID,Safaralizadeh Reza1ORCID,Banan Khojasteh Seyed Mahdi1ORCID,Sam Mohammad Reza2ORCID,Latifi-Navid Saeid3ORCID,Hussen Bashdar Mahmud4ORCID,Shadbad Mahdi Abdoli5ORCID,Baradaran Behzad6ORCID

Affiliation:

1. Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran

2. Department of Cellular and Molecular Biotechnology, Institute of Biotechnology, Urmia University, Urmia, Iran | Department of Biotechnology, Artemia and Aquaculture Research Institute, Urmia University, Urmia, Iran

3. Department of Biology, Faculty of Sciences, University of Mohaghegh Ardabili, Ardabil, Iran

4. Pharmacognosy Department, College of Pharmacy, Hawler Medical University, Erbil, Kurdistan, Kurdistan Region,Iraq

5. Pharmacognosy Department, College of Pharmacy, Hawler Medical University, Erbil, Kurdistan, Kurdistan Region, Iraq

6. Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran

Abstract

Background: Growing evidence indicates that miRs have critical activities in adjusting cellular processes, e.g., cell death, proliferation, and cell-cycle. Introduction: This study aimed to provide a concise review of the recent findings regarding tumoral miRs and the cross-talk between miRs and epigenetic factors. Results: Like the protein-coding genes, the expression levels of miRs are mediated by various transcriptional networks. Indeed, the expression of miRs could be epigenetically modulated by DNA methylation factors and histone modifiers. Furthermore, miRs can suppress critical factors, which mediate epigenetic modifications. Besides, miRs have been implicated in cancer development, metastasis, and chemo-resistance. The aberrant expression of miRs and dysregulated modulatory circuits between miRs and epigenetic factors participate in tumor progression. Conclusion: Identifying tumoral miRs can provide ample opportunity to overcome chemo- resistance and bring a forefront treatment for affected patients.

Funder

University of Tabriz

Publisher

Bentham Science Publishers Ltd.

Subject

Pharmacology,Molecular Medicine,Drug Discovery,Biochemistry,Organic Chemistry

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