Affiliation:
1. Institute of Chemistry, St. Petersburg State University, St. Petersburg, Russian Federation
Abstract
The last decade has been characterized by the development and approval of
pretomanid and delamanid, which are nitroimidazole based drugs for multidrug -resistant
tuberculosis. This attracted renewed attention to the nitroheterocyclic scaffolds as a
source of safe and efficient antimicrobial agents. While the primary focus is still on nitrofurans
and nitroimidazoles, well known as bioreducible prodrugs, a number of studies
have been published on other 5-membered nitroheteroaromatic compounds. The latter not
only show promising antimicrobial activity but also demonstrate modes of action different
from the conventional reductive activation of the nitro group. Considering the potential of
these efforts to impact the continuing race against drug-resistant pathogens, herein we review
non-furan/imidazole-based 5-membered nitroheteroaromatics investigated as antimicrobial
agents in 2010-2020.
Funder
Russian Federation Government Mega grant
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmacology,Molecular Medicine,Drug Discovery,Biochemistry,Organic Chemistry
Cited by
7 articles.
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