Affiliation:
1. CAS Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China
Abstract
:
Marine organisms are abundant sources of bioactive natural products. Among metabolites
produced by sponges and their associated microbial communities, halogenated natural compounds accounted
for an important part due to their potent biological activities. The present review updates and
compiles a total of 258 halogenated organic compounds isolated in the past three decades, especially
brominated derivatives derived from 31 genera of marine sponges. These compounds can be classified as
the following classes: brominated polyunsaturated lipids, nitrogen compounds, brominated tyrosine derivatives
and other halogenated compounds. These substances were listed together with their source organisms,
structures and bioactivities. For this purpose, 84 references were consulted.
Funder
National Natural Science Foundation of China
Key research and development project of Shandong province
Key Research Program of Frontier Sciences, CAS
Project of Discovery, Evaluation and Transformation of Active Natural Compounds, Strategic Biological Resources Service Network Programme of Chinese Academy of Sciences
Shandong Provincial Natural Science Foundation for Distinguished Young Scholars
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmacology,Molecular Medicine,Drug Discovery,Biochemistry,Organic Chemistry
Cited by
9 articles.
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