Mitophagy: A Novel Therapeutic Target for Treating DN-Reference-Cited by-同舟云学术

Mitophagy: A Novel Therapeutic Target for Treating DN

Published:2021-05-28 Issue:14 Volume:28 Page:2717-2728
ISSN:0929-8673
Container-title:Current Medicinal Chemistry
language:en
Short-container-title:CMC

Author:

Yang Ming¹^ORCID,Li Chenrui¹^ORCID,Yang Shikun²^ORCID,Xiao Ying¹^ORCID,Chen Wei¹^ORCID,Gao Peng¹^ORCID,Jiang Na¹^ORCID,Xiong Shan¹^ORCID,Wei Ling¹^ORCID,Zhang Qin¹^ORCID,Yang Jinfei¹^ORCID,Zeng Lingfeng¹^ORCID,Sun Lin¹^ORCID

Affiliation:

1. Department of Nephrology, The Second Xiangya Hospital Central South University, Hunan Key Laboratory of Kidney Disease and Blood Purification, No. 139 Renmin Middle Road, Changsha, Hunan, China

2. Department of Nephrology, the third Xiangya Hospital, Central South University, Changsha, Hunan, China

Abstract

Diabetic nephropathy (DN) is a common microvascular complication of diabetes and one of the leading causes of end-stage renal disease. Tubular damage is an early change and characteristic of DN, and mitochondrial dysfunction plays an important role in the development of DN. Therefore, the timely removal of damaged mitochondria in tubular cells is an effective treatment strategy for DN. Mitophagy is a type of selective autophagy that ensures the timely elimination of damaged mitochondria to protect cells from oxidative stress. In this review, we summarize our understanding of mitochondrial dysfunction and dynamic disorders in tubular cells in DN and the molecular mechanism of mitophagy. Finally, the role of mitophagy in DN and its feasibility as a therapeutic target for DN are discussed.

Publisher

Bentham Science Publishers Ltd.

Subject

Pharmacology,Molecular Medicine,Drug Discovery,Biochemistry,Organic Chemistry

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