Exosome-Mediated Drug Delivery for Cell-Free Therapy of Osteoarthritis

Author:

Duan Li1ORCID,Xu Xiao1ORCID,Xu Limei1ORCID,Chen Hongfei2ORCID,Li Xingfu1ORCID,Alahdal Murad1ORCID,Xiao Yin3ORCID,Liang Yujie2ORCID,Xia Jiang2ORCID

Affiliation:

1. Department of Orthopedics, Shenzhen Intelligent Orthopaedics and Biomedical Innovation Platform, Guangdong Artificial Intelligence Biomedical Innovation Platform, Shenzhen Second People’s Hospital, the First Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen 518035, China

2. Department of Chemistry, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China

3. Institute of Health and Biomedical Innovation, Faculty of Science and Engineering, Queensland University of Technology, Kelvin Grove Campus, Brisbane QLD 4059, Australia

Abstract

Osteoarthritis (OA) is a degenerative disease of cartilage and bones, which results in severely compromised quality of life in the aged population. However, currently, no ideal treatment strategies have been developed to prevent OA progression. Cell therapies, such as chondrocyte and MSC transplantation, have been extensively tested and evaluated in clinical trials. Yet, to day, the clinical efficacy of articular injection of stem cells in OA has not been convincingly demonstrated. Recent studies have indicated that exosomes, one type of Extracellular Vesicles (EVs) play an important regulatory role in the pathogenesis of OA, suggesting the prospective therapeutic application of exosomes in OA treatment. In this review, we systematically summarized the paracrine effects of exosomes derived from MSCs and chondrocytes on cartilage regeneration, the use of exosomes as a delivery vehicle for OA treatment, the effectiveness of such treatments in OA animal models, and the future perspective of exosome-mediated drug delivery as a cell- free therapy of OA.

Funder

Science and Technology Planning Project of Shenzhen Municipality

Key Program of Natural Science Foundation of Guangdong Province

National Natural Science Foundation of China

Publisher

Bentham Science Publishers Ltd.

Subject

Pharmacology,Molecular Medicine,Drug Discovery,Biochemistry,Organic Chemistry

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