Affiliation:
1. School of Pharmacy, Guangdong Medical University, 1 Xincheng Ave, Songshan Lake Technology Park, Dongguan, Guangdong 523808, China
Abstract
Sigma-2 receptor plays key roles in promoting tumor cell apoptosis, enhancing efficacy
of anti-tumor drugs, blocking signal transduction controlled by Aβ oligomers, regulating
Ca2+ homeostasis and protecting nerve cells. Studies indicated that sigma-2 receptor may
be closely coupled with ROS, LDL, mTOR, RAS, PLC/PKC, lysosomal autophagy and mitochondrial
super oxidative stress. In addition, the high expression of this receptor in proliferating
cells and nerve cells indicates that sigma-2 receptor is an ideal molecular target for imaging
and therapeutic development for cancer, Alzheimer's disease, schizophrenia and traumatic
brain injury. Various sigma-2 agonists have shown promising anticancer activities, while
sigma-2 antagonists have displayed neuroprotection and inhibition of Aβ oligomers in the
brain of Alzheimer's disease patients. Thus, both sigma-2 agonists and antagonists are potentially
useful therapeutics for the management of cancer and neurodegenerative disorders.
Funder
Guangdong Science Foundation
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmacology,Molecular Medicine,Drug Discovery,Biochemistry,Organic Chemistry
Cited by
10 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献