Biomarkers in Aortic Valve Stenosis and their Clinical Significance in Transcatheter Aortic Valve Implantation
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Published:2019-04-22
Issue:5
Volume:26
Page:864-872
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ISSN:0929-8673
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Container-title:Current Medicinal Chemistry
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language:en
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Short-container-title:CMC
Author:
Toutouzas Konstantinos1, Stathogiannis Konstantinos1, Latsios George1, Synetos Andreas1, Drakopoulou Maria1, Penesopoulou Vicky1, Michelongona Archontoula1, Tsiamis Eleftherios1, Tousoulis Dimitris1
Affiliation:
1. First Department of Cardiology, Hippokration Hospital, Athens Medical School, Athens, Greece
Abstract
Aortic valve stenosis is one of the most common valvular heart disorders and the
prevalence will rise as the population ages. Once symptomatic patients with aortic valve
stenosis tend to fare worse with high mortality rates. Aortic valve replacement is indicated in
these patients and besides the standard surgical replacement, a less invasive approach, transcatheter
aortic valve implantation, has gained momentum and has showed promising and
solid results in patients with high surgical risk. An important aspect of evaluating patients
with aortic valve stenosis is the ability to choose the best possible candidate for the procedure.
In addition, predicting the short and long-term clinical outcomes after the valve replacement
could offer the treating physicians a better insight and provide information for optimal therapy.
Biomarkers are biological parameters that can be objectively measured and evaluated as
indicators of normal biological processes and are easily monitored. The aim of this review is
to critically assess some of the most widely used biomarkers at present (natriuretic peptides,
troponins, C-reactive protein) and provide an insight in novel biomarkers that are currently
being investigated (galectin-3, growth differentiation factor-15, microRNAs) for possible diagnostic
and prognostic use in aortic valve stenosis and transcatheter aortic valve implantation
respectively.
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmacology,Molecular Medicine,Drug Discovery,Biochemistry,Organic Chemistry
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