Synthesis, Characterization, DPPH, Ferric Reducing, and Ferrous Ion- Chelating Activities of Isophthalate Schiff Bases

Abstract

Aims: The synthesis of bioactive compounds has antioxidant potential. Background: All aerobic bodies including human beings, have antioxidant defense systems that protect them from oxidative damage, and many enzymes to remove or heal damaged molecules. However, this normal antioxidant mechanism can be incompetent, and hence dietary intakes of antioxidant compounds are important. Objective: Synthesis of isophthalate Schiff base derivatives 1-14 and screened for their antioxidant activities (DPPH, ferrous ion Fe2+ chelating and ferric Fe3+ reducing activities) Method: This study aimed to synthesize isophthalate Schiff base derivatives 1-14 and screen them for their antioxidant activities (DPPH, ferrous ion Fe2+ chelating, and ferric Fe3+ reducing activities). Result: Compounds were screened for their antioxidant activities (DPPH, ferrous ion Fe2+ chelating, and ferric Fe3+ reducing activities). Most of the compounds showed significant antioxidant activities. A structure- activity relationship has also been discussed. Conclusion: Most of the synthetic isophthalate Schiff bases were found to be moderately active when screened for their antioxidant activities by three assays such as DPPH radical scavenging, ferrous ionchelating, and ferric reducing activities. These moderately active compounds can serve as lead molecules to further modify the structure and identify more powerful antioxidant agents.