Affiliation:
1. Center for Environmental Research & Studies, Jazan University, 42145, Saudi Arabia
2. Department of Chemistry,
College Science, Mahliya, Jazan University, 42145, Saudi Arabia
Abstract
Background:
Background: Sulfur serves as a versatile element and an essential constituent of pharmaceutical
industries, natural compounds, proteins, and biological systems. One of the fundamental
constituents of sulfur is thiouracil, which forms several derivatives, including 6-
methylthiouracil, 6-methyl-2-thiouracil, and 6-propylthiouracil. These derivatives act as effective
chelating agents and can form complexes with metal ions.
:
Compared with other metals, ruthenium possesses unique chemical properties that make it an ideal
therapeutic agent. Therefore, this study reports on the propylthiouracil: Ru(III) complex, considering
these essential facts.
Methods:
An equimolar amount of ruthenium trichloride 3.34 x 10-5 M was added to various aliquots
ranging from 0.4 mL to 8.8 mL of 3.26 x 10−5 M propylthiouracil. The volume was adjusted
to 10 mL with double distilled water. After letting the solution stand for 10 min, we recorded the
absorbance of different sets at λmax 376 nm. The Beer-Lambert's law graph demonstrated linearity
in the concentration range of 3.18 x101 μgmL-1 to 7.96 x102 μgmL-1, with a linear regression
equation of Y = 0.0354 + 0.1109 X. We determined the effective molar absorptivity (ε) to be
6.609 x 102 Lmole-1 cm-1, and the relative standard deviation (RSD %) was ± 0.34%.
Results:
At room temperature, a yellow-colored complex of propylthiouracil: Ru(III) was formed
within 10 min, with a λmax of 376 nm and constant color intensity for 24 h. We confirmed and
characterized the formed complex using FTIR, ESR, 1HNMR, thermal analysis, magnetic susceptibility,
and powder X-ray.
Conclusion:
This approach is notable for its precision, accuracy, rapidity, cost-effectiveness, and
applicability in tablet form. The novel propylthiouracil: Ru(III) complex offers several advantages,
including stability, low absorbance, and no interference with water-soluble ions, eliminating
the need for an organic solvent to extract the reaction product. Therefore, this approach
could be recommended for quality control in the pharmaceutical industry.
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmaceutical Science,Molecular Medicine,Biochemistry,Biophysics
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