Affiliation:
1. Department of Pharmaceutical Analysis and Quality Assurance, Roland Institute of Pharmaceutical Sciences, Berhampur, India
Abstract
Abstract:
The application of various sophisticated analytical tools and techniques is essential for
estimating an active pharmaceutical ingredient present in either biofluids or pharmaceutical dosage
forms. Reporting the multiple analytical methods used to quantify esomeprazole magnesium
trihydrate, a proton pump inhibitor, is the ultimate goal of this review article.
This article deals with a detailed discussion of different reported analytical procedures along with
their pros and cons and their relevant criteria for quantifying the drug. Various analytical techniques
like UV-Visible spectrophotometry, HPLC, HPTLC, hyphenated techniques, etc., are developed
to assess the esomeprazole magnesium trihydrate in bulk materials, different pharmaceutical
formulations, and biological matrices.
Literature survey confirmed that the hyphenated techniques and chromatographic techniques are
the best tools for biological matrices. Spectroscopic methods like UV and visible techniques are
widely used for pharmaceutical matrices. All of the reported methods are accurate, precise, costeffective,
and sensitive.
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmaceutical Science,Molecular Medicine,Biochemistry,Biophysics
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